ACTA Pharmaceutica Sciencia 2018 , Vol 56 , Num 3
Development of Directly Compressible Excipients from Phoenix dactylifera (Date) Mucilage and Microcrystalline Cellulose using Co-Processing Techniques
Olufunke D. Akin-Ajani 1 Tolulope O. Ajala 1 Uchenna M. Okoli 1 Ozioma Okonta 1
1 University of Ibadan, Faculty of Pharmacy, Department of Pharmaceutics & Industrial Pharmacy, Ibadan, Nigeria
DOI : 10.23893/1307-2080.APS.05615 The objective of this study was to harness the excipient potential of date mucilage by co-grinding and co-fusing with avicel for enhanced performance in the directcompression of metronidazole.

Co-grinding and co-fusing of parent polymers were done using established methods and excipients were used in the direct-compression of metronidazole tablets.

The shape and surface morphology of the particles of date mucilage (DAM) and co-processed excipients were generally granular, rough and irregular. There was a significant improvement in the disintegration of tablets prepared using the coprocessed excipients in comparison to that prepared using DAM alone. The disintegration time for tablets prepared using co-fused excipients was lower than that of co-grinded additives although the differences were not significant (p > 0.05).

Generally, the co-processed excipients improved the mechanical and disintegration properties of the tablets produced compared to tablets prepared using DAM alone and could be further developed as direct-compression excipients. Keywords : Date mucilage, avicel, co-processing, metronidazole tablets

Istanbul Medipol University