ACTA Pharmaceutica Sciencia 2017 , Vol 55 , Num 4
Anti-inflammatory and Hypoglycemic Activities of Alpha-pinene
Hanefi Özbek 1 Betül Sever Yılmaz 2
1 Istanbul Medipol University, School of Medicine, Department of Medical Pharmacology
2 Ankara University, Faculty of Pharmacy, Department of Pharmacognosy
DOI : 10.23893/1307-2080.APS.05522 The aim of this study is to investigate the anti-inflammatory and hypoglycemic activities of alpha-pinene, and to find the median lethal dose (LD50) level in mice.

Lethal dose levels of alpha-pinene were investigated using a probit analysis method. For the anti-inflammatory activity measurement seven different groups were established and alpha-pinene was administered in four different doses: 0.05, 0.10, 0.25 and 0.50 mL/kg. For the evaluation of hypoglycemic activity six different groups, consisting of diabetic and healthy mice, were established.

The strongest anti-inflammatory activity of alpha-pinene was observed with a 0.50 mL/kg dosage. The median effective dose (ED50) value of alpha-pinene was found to be 0.039 mL/kg. In diabetic mice ?-pinene showed significant levels of hypoglycemic activity at the 2nd and 24th hours. LD50 level of ?-pinene was determined to be 2.076 mL/kg.

As a result, we conclude that alpha-pinene is a molecule that displays hypoglycemic and anti-inflammatory activities. Keywords : Alpha-pinene, anti-inflammatory activity, hypoglycemic activity, mice, rats.

Istanbul Medipol University