¹Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
²Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran DOI : 10.12991/jrp.2019.133 The objective of the current study was to design a suitable model to predict the cytotoxicity induced by SiO₂ and TiO₂ nanoparticles in different conditions using computational models. To achieve this, we employed various statistical approaches such as linear regression, as well as artificial neural networks and support vector machine (non-linear models). The effective input parameters of the SiO₂ nanoparticles were particle size, particle concentration, and cell exposure time. In the case of the TiO₂ nanoparticles, the particle size and concentration served as input variables. Cell viability was considered the output response for both nanoparticles. The modeling was performed using both linear and non-linear methods. In addition, an external validation analysis was conducted to evaluate the predictability of the models by splitting the data into training and test data. The best models to predict cell viability were the models developed by artificial neural network. The results of this investigation indicate that non-linear models could be superior to linear models in predicting cell viability for SiO₂ and TiO₂ nanoparticles. Keywords : Artificial neural network; cytotoxicity; modeling; nanoparticles