¹Van Yüzüncü Yıl University, Faculty of Pharmacy, Department of Analytical Chemistry, 65080 Van, Turkey
²Van Yüzüncü Yıl University, Faculty of Science, Department of Analytical Chemistry, 65080 Van, Turkey DOI : 10.12991/jrp.2018.88 This paper examined for the first time the possibilities of the usage of the cathodically pretreated boron-doped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using square-wave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 μg mL^-1 (1.73x10^-5 -3.47x10^-4 M). A detection limit of 1.21 μg mL^-1 (5.06x10^-6 M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations. Keywords : Salbutamol; boron-doped diamond electrode; square-wave adsorptive stripping voltammetry; pharmaceutical formulations