Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 1
Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application
Seda RENÇBER1,Ece ÖZCAN BÜLBÜL2,Neslihan ÜSTÜNDAĞ OKUR3,Zeynep AY ŞENYİĞİT1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, İzmir Katip Celebi University, Izmir, Turkey
2Department of Pharmaceutical Technology, Faculty of Pharmacy, İstinye University, İstanbul, Turkey
3Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, İstanbul, Turkey
DOI : 10.35333/jrp.2021.291 This study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 29–33°C. All prepared in situ gels showed non-Newtonian pseudoplastic flow (shear thinning system) like tear fluid at 32 ± 0.1ºC. The results of in vitro dissolution studies showed that at least 65% of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis. Keywords : Fusidic acid; in situ gel; poloxamer; NaCMC; ocular
Marmara University