Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 1
Hepatoprotective activity of Ehretia microphylla on paracetamol induced liver toxic rats
Kumarapalayam Ramakrishnan YUVARAJA1,Arockiasamy SANTHIAGU2,Shabbeer JASEMINE3,Kasiramar GOPALASATHEESKUMAR4
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, KMCH College of Pharmacy, Coimbatore, Tamil Nadu-641048, India
2Department of Biotechnology, School of Biotechnology, National Institute of Technology, Calicut, Kerala, India
3Director, One Beat College of Medical Sciences, Bhira, Uttar Pradesh, India
4Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Tamil Nadu - 608002, India
DOI : 10.35333/jrp.2021.286 World wide liver toxicity is the most prevelent healthcare problem. We need to address this with herbal based medicine because herbal products have high efficacy and less side effects. Many of the Ehretia genus (Boraginaceae) have the hepatoprotective property. But Ehretia microphylla (EM) was not reported yet for its hepaptoprotective potential. Therefore the current research was aimed to evaluate the hepatoprotective action of EM. The hepatoprotective activity of EM was assessed against the paracetamol induced liver toxic rats. The chloroform and ethyl acetate extracts of EM were selected for the investigation. The dose was selected by using OECD423 guidelines. The paracetamol intoxicated rats were elevated the liver functional parameters like serum SGOT, SGPT and ALP levels and also triglyceride and total cholesterol. These elevated parameters were significantly lowered in chloroform and ethyl acetate extracts of EM pretreated rats when compared with silymarin. However the antioxidant markers including CAT, SOD, GSH and GPx were significantly increased in EM extract treated rats when compared with paracetamol induced toxic rats. It revealed the plant extracts of EM has significant hepatoprotective activity. Further, this research will useful for the isolation of active principles from EM and determining its molecular mechanisms. Keywords : Liver; silymarin; antioxidant; Boraginaceae; Ehretia
Marmara University