Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2020 , Vol 24 , Issue 6
The formulation of ginger oil nanoemulsions of three varieties of ginger (Zingiber officinale Rosc.) as natural antioxidant
Indah Yulia NINGSIH1,Husniya FARADISA1,Mei Dwi CAHYANI1,Viddy Agustian ROSYIDI2,Mochammad Amrun HIDAYAT1
1Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Jember, Jember, Jawa Timur, Indonesia
2Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Jember, Jember, Jawa Timur, Indonesia
DOI : 10.35333/jrp.2020.251 One of traditional plants in Indonesia that could be potentially developed as antioxidant is ginger (Zingiber officinale Rosc.). There are three varieties, namely elephant ginger, yellow ginger, and red ginger. Its contents mainly essential oil consisted of many antioxidant compounds. Nevertheless, the use of ginger oil in topical dosage form formula is less effective, unstable, and volatile which affects its bioavailability. In this study, nanoemulsion formulas of ginger oil were optimized according to the ratio of tween 80 as surfactant and ethanol as cosurfactant using simplex lattice design (SLD) method. The optimum nanoemulsion formulas of each varieties were characterized and the result showed that nanoemulsion of yellow ginger oil had the highest percentage transmittance (99.676 ± 0.096%) and half-maximal inhibitory concentration (IC50) value (3.010 ± 0.008 mg/mL). Furthermore, all optimum formulas had complied the other nanoemulsion specifications. The study indicated that nanoemulsion formulas of three varieties of ginger essential oils could be developed as potential antioxidant agent. Keywords : Ginger oil; nanoemulsion; tween 80; ethanol; antioxidant
Marmara University