Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2020 , Vol 24 , Issue 1
Design and development of melt solidification of meloxicam for enhancement of solubility and dissolution
Anilkumar J SHINDE1,Rahul S DALAVI2,Harinath N MORE1
1Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India
2Raptim Laboratories, Mumbai, Maharashtra, India
DOI : 10.35333/jrp.2020.113 The objective of the present study was to prepare an amorphous system of BCS Class 2 drug meloxicam (MLX) to improve its solubility and dissolution by using the melt solidification techniques. About 40% of new chemical entities do not reach to market due to its poor aqueous solubility. Melt solidification technique is an important process to control the transition from liquid in to solid phase to obtain product in an amorphous form. During the process of heating, some solid gets melted and if quench cooled, instead of crystallizing gets converted to amorphous solid form appearing as that of glass, which improve dissolution and bioavailability of drugs. Physical mixtures of MLX were prepared by melt solidification technique using polymer (soluplus). The solubility and dissolution studies for the meloxicam and batches were conducted in a phosphate buffer (pH 6.8). The fourier transform infrared(FTIR) spectrophotometry, X-ray diffraction microscopy(XDM) and Differential scanning calorimetry(DSC) studies were conducted to evaluated pure drug and optimized batch(MS7). Saturation solubility and % drug release showed the improve solubility and dissolution, results suggest that optimized batch (MS7) containing drug and polymer in proportion of 1:4 (MLX:soluplus) was a successful enhancing the solubility and dissolution of MLX. The % crystallinity of MLX in amorphous sample was 18.60%, which indicates significant decrease in crystallinity of MLX in an amorphous system. The best fit model of optimized batch (MS7) was zero order model, showing the %drug release 96.83% and R2 0.9904. The present investigation, successfully enhancement solubility and dissolution of MLX by using melt solidification technique. Keywords : Meloxicam; melt solidification; dissolution; solubility; soluplus
Marmara University