Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2014 , Vol 18 , Issue 1
Antioxidant, antimicrobial and anticarcinogenic activities of Sambucus ebulus L. flowers, fruits and leaves
Zehra Ilke MERIC1, Leyla BITIS2, Seher BIRTEKSOZ TAN3, Suna OZBAS TURAN4, Julide AKBUGA4
1Yeni Yüz Yıl University, Faculty of Pharmacy, Department of Pharmacognosy, Istanbul, Turkey
2Marmara University, Faculty of Pharmacy, Department of Pharmacognosy, Istanbul, Turkey
3Istanbul University, Faculty of Pharmacy, Pharmaceutical Microbiology, Istanbul, Turkey
4Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, Istanbul, Turkey
DOI : 10.12991/mpj.201414122 The aim of this study was to evaluate the antioxidant, antimicrobial and anticarsinogenic activities of methanol extract obtained from flowers, fruits and leaves of Sambucus ebulus L. Free radical scavenging activities and total phenolic contents of the species were assayed by DPPH method and Folin–Ciocalteu method, respectively. The antimicrobial activity of the extracts were tested by the micro-broth dilution method against seven microbial species. L929 (ATCC, CCL-1) mouce fibroblast cell line was used for the determiation of in vitro citotoxicity activity and HeLa (ATCC, CCl-2) human cervics adenocarcinoma cell line was used for the determination of anticarcinogenic and growth inhibition activity. Leaves of Sambucus ebulus L showed the strongest antioxidant activity and also leaves of plant has highest phenolic content, Sambucus ebulus L. exracts were found to have no significant activity against any strains of bacteria. Only Sambucus ebulus fruit extract has shown moderate effect against Candida albicans. In 10μg/mL concentration the highest anticarcinogenic activity were found in leaves extract, in addition that none of the extracts were not found cytotoxic. Keywords : Sambucus ebulus, antioxidant, antimicrobial, anticarsinogenic, cytotoxic
Marmara University