Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2012 , Vol 16 , Issue 1
Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA
Ayşe Selcen Alpan1, Övgü Yılmaz2, Ozan Kılıçkaya2, Pınar Kara2, Hasan Semih Güneş1, Mehmet Şengün Özsöz2
1Ege Üniversitesi, Eczacılık Fakültesi Farmasötik Kimya Anabilim Dalı, İzmir, Türkiye
2Ege Üniversitesi, Eczacılık Fakültesi Analitik Kimya Anabilim Dalı, İzmir, Türkiye
DOI : 10.12991/201216420 In this study, synthesis and determination of interaction between DNA and 1Hbenzimidazole derivatives has been performed by using electrochemical genosensor technology. Detection of DNA – drug interaction mechanism relies on monitoring Differential pulse voltammetric (DPV) responses of drugs at disposable graphite electrodes (DGEs). Interaction of 7 different benzimidazole derivates between double-stranded (ds) and singlestranded (ss) DNA were observed by changing the voltammetric signals of drugs at the detection limits of 0.62 nM of compound 1, 1.23 nM of 2, 1.26 nM of 3, 1.08 nM of 4, 1.13 nM of 5, 0.69 nM of 6 and 0.42 nM of 7, respectively. Keywords : 1H-benzimidazole, electrochemical genosensor, DNA-drug interaction, synthesis
Marmara University