Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Quarterly (January-April-July-October) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2011 , Vol 15 , Issue 2
Synthesis and anticonvulsant activity of substituted thiourea derivatives
Ahmet Özgür Çelen1, Bedia Kaymakçıoğlu1, Salih Gümrü2, Hale Zerrin Toklu2, Feyza Arıcıoğlu2
1Marmara Üniversitesi Eczacılık Fakültesi, Farmasötik Kimya Anabilim dalı, İstanbul, Türkiye
2Marmara Üniversitesi Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye
DOI : 10.12991/201115430 Twelve new thiourea derivatives were prepared by the reacting of 4-aminophenylacetic acide with substituted isothiocyanates. Their chemical structures were proved by means of IR, 1H-NMR, mass spectroscopic and elemental analyses. These compounds were tested at dose of 50 mg/kg for their anticonvulsant activity using by pentylenetetrazole induced seizure (PTZ) and maximal electroshock seizure (MES) tests in mice. Compound 1b, (4-{[(4-chlorophenyl)thiocarbamoyl]amino}phenyl)acetic acid, was found to be more active than the other tested compounds. The compound 1b reduced convulsions in all types of grades (from grade I to V), therefore it increased convulsive threshold. It also increased onset time from 1.20 to 2.58 sec. and survival % from 50 to 95. Keywords : Synthesis, thiourea, anticonvulsant activity
Marmara University