Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2010 , Vol 14 , Issue 2
Synthesis and cytotoxic activity of some 1,2,4-triazoline-3-thione and 2,5-disubstituted- 1,3,4-thiadiazole derivatives
Sevgi Karakuş1, Ufuk Çoruh2, Bilgehan Barlas-Durgun1, Ezequiel M. Vázquez-López3, Suna Özbaş-Turan1, Jülide Akbuğa1, Sevim Rollas1
1Marmara Üniversitesi, Eczacılık Fakültesi, İstanbul, Türkiye
2Ondokuz Mayıs Üniversitesi, Eğitim Fakültesi, Samsun, Türkiye
3Universidade de Vigo, Facultade de Ciencias- Química, Vigo, Galicia, İspanya
DOI : 10.12991/201014454 In this search, a series of 5-[4-(4-fluorobenzoylamino)phenyl]-2-substitutedamino- 1,3,4-thiadiazole ( 2a-g ) and 5-[4-(4-fluorobenzoylamino)phenyl]-4-substituted-2,4-dihydro- 3H-1,2,4-triazo-le-3-thione ( 3a-f ) derivatives were synthesized and characteristed by elemental analysis, UV-visible, IR, 1H-NMR, MS spectral data and X-ray crystallograpy (3b). Cytotoxic activity of six prototype compounds (2a, 2d, 2e, 3a, 3d and 3e) were evaluated by using HeLa (ATCC CCL-2) and normal cell lines according to procedures of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] Assay [Cell Proliferation Kit I (MTT) Roche-Germany]. Keywords : Cytotoxic activity, 1,2,4-triazoline-3-thione, 2,5-disubstituted-1,3,4-thiadiazole, mtt assay, x-ray crystallograpy
Marmara University