¹Department of Pharmacy, Bharati Vidyapeeth College of Pharmacy, Sector 8, CBD Belapur, Navi Mumbai, 400614 India DOI : 10.29228/jrp.674 Loratadine, a BCS class II drug, is used as an antihistaminic in the treatment of allergies. It has a poor water solubility and a low bioavailability as a result of significant first-pass hepatic metabolism after oral administration. Nanofibers, which are strings of polymeric fibres with diameters smaller than 1 micron, are one such strategy. They are superior to other varieties of the substance in a number of ways, including surface area to volume ratio, elasticity, and mechanical properties. Typically, electrospinning is used to make nanofibers. These properties could be utilized for overcoming the problems associated with the loratadine. Thus, the aim of this study was to formulate loratadine nanofiber film for buccal application. The formulation of loratadine nanofiber films involved electrospinning a solution containing a definite ratio of Polyvinylpyrrolidone (PVP) and Ethyl Cellulose (EC). The optimized film was characterized by SEM, DSC and FTIR. Mucoadhesion strength, ex-vivo permeation tests, and invitro drug release were all assessed for the end formulation. The results showed that the drug was evenly dispersed and enclosed within the nanofiber matrix. The film made of nanofibers showed consistent morphology and enhanced drug penetration and release. The developed Loratadine-loaded electrospun nanofiber film may therefore be used as an improvement over conventional dosage forms by increasing patient compliance. Keywords : Loratadine; nanofiber; electrospinning; buccal delivery; PVP, ethyl cellulose