Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 2
Preparation and in vitro characterization of laminarin based hydrogels
Sıla TÜMEN ERDEN1,Ceyda EKENTOK ATICI2,Birnur CÖMEZ2,Ali Demir SEZER2
1Dem Pharmaceuticals, Research and Development Department, İstanbul, Turkey
2Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Marmara University, M.Ü. Recep Tayyip Erdoğan Külliyesi, Başıbüyük Yolu, 34854 4/A, Başıbüyük, İstanbul, Turkey
DOI : 10.29228/jrp.7 Hydrogels are one of the most effective pharmaceutical forms because of several advantages in the treatment of burn and wound healings. Laminarin is a storage polysaccharide derived from brown algae and member of the 1-3-β-D-glucan family. It is a heparin-like molecule and plays role in hemostasis, regulation of cell growth and regeneration. Also, indirectly functional in neovascularization. In addition, accelerates the formation of fibroblast activity and re-epithelization. Aim of this study is prepare laminarin hydrogels and evaluate the in vitro characteristics of hydrogels for use in various wounds. For this purpose, different hydrogel formulations prepared and examined, and evaluated by water absorption capacity, viscosity, rheological and mechanical properties and bioadhesion. It was observed that hydrogels prepared with laminarin are an ideal wound dressing as expected. Keywords : Hydrogel; laminarin; carboxymethylcellulose; polyvinylpyrrolidone; wound healing
Marmara University