Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 2
Phytochemical studies on the seeds, pseudofruits, and roots of Rosa pimpinellifolia
Leyla GÜVEN1,Ufuk ÖZGEN2,Hasan SEÇEN3,Sıla Özlem ŞENER2,Merve BADEM4,Gonca ÇELİK5,Nurettin YAYLI2
1Department of Pharmaceutical Botany, Faculty of Pharmacy, Atatürk University, Erzurum, 25240, Turkey
2Department of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, 61080, Turkey
3Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, 25240, Turkey
4Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, 61080, Turkey
5Department of Chemistry, Faculty of Sciences, Karadeniz Technical University, Trabzon, 61080, Turkey
DOI : 10.29228/jrp.6 The roots and pseudofruits of Rosa pimpinellifolia (Rosaceae) are used in traditional medicine as hemorrhoids, various infections, abdominal pain complaints, heart disease, flu, cold, and anemia treatment in Turkey. In this study, the phytochemical composition of the R. pimpinellifolia was revealed by using chromatographic and spectroscopic techniques. Two condensed tannin precursor, (-)-catechin (1), the mixture of catechin and epicatechin (2) and three triterpenoid glycosides, kaji-ichigoside F1 (3), 2α,3β,19α trihydroxyurs-12-en-28-O-β-D-glucopyranoside (4), 2α,3β,19α,23β-tetrahydroxyurs-12-en-28-O-β-D-glucopyranoside (5) were isolated from the roots of R. pimpinellifolia. The isolation studies were performed by column chromatography. The chemical structures of the isolated compounds were elucidated with 1H and 13C NMR spectroscopy. Total phenolic compound contents were determined as 31.1937 mg/g dry extract in the pseudofruit; 9.8909 mg/g dry extract in the root via HPLC. The seeds of R. pimpinellifolia were extracted with diethyl ether in Soxhlet apparatus. The methyl esters of fatty acid were obtained from fixed oil and analyzed by GC/MS. The total ratio of unsaturated fatty acids in the seeds was 93.4%; containing 51.40% ratio of linoleic acid and 41.20% ratio of homo-γ-linolenic acid. Keywords : Rosa pimpinellifolia; Triterpenoid glycosides; phenolic compounds; fatty acid
Marmara University