Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 2
Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents
Sevil ŞENKARDEŞ1,Merve Eylül KIYMACI2,Kübra KALE3,İsa Murat KOZANOĞLU3,Banu KAŞKATEPE4,Şükriye Güniz KÜÇÜKGÜZEL1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Başıbüyük 34854 İstanbul, Turkey
2Department of Pharmaceutical Microbiology, Gulhane Faculty of Pharmacy, University of Health Sciences, Etlik-Keçiören 06018 Ankara, Turkey
3Faculty of Pharmacy, Marmara University, Başıbüyük 34854 İstanbul, Turkey
4Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ankara University, Yenimahalle 06560 Ankara, Turkey
DOI : 10.29228/jrp.4 In this study, some N′‑(substituted arylmethylidene)-4‑nitrobenzenesulfonohydrazide derivatives were synthesis by reacting various aldehydes and 4‑nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed by IR, 1H-NMR and TOF-MS (compounds 3b and 3e) spectroscopic data besides elementel analyses results. The antibacterial activities of these compounds were examined against some bacteria species. The compounds showed the highest activity against Pseudomonas aeruginosa ATCC 27853. Also, anti-quorum sensing activities have been determined using a biosensor bioassay with Chromobacterium violaceum CV026 and the signaling molecule N-hexanoyl-L-homoserine lactone. All the compounds were subjected for ADME predictions by computational method. Keywords : Sulfonyl hydrazone; hydrazide; MIC; antibacterial activity; quorum sensing
Marmara University