Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 1
Preparation and in vitro evaluation of Tacrolimus loaded liposomal vesicles by two methods: A comparative study
Shammy JINDAL1,Rajendra AWASTHI1,Dhananjay SINGARE3,Giriraj T. KULKARNI1
1Amity Institute of Pharmacy, Amity University Uttar Pradesh, Sector-125, Noida 201313, India
2Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India
3Piramil Healthcare Ltd., Ahmedabad, Gujarat, India
DOI : 10.35333/jrp.2021.292 Psoriasis is an autoimmune disorder characterized by hyper proliferation of the epidermal layer at the typical body sites, including nails, scalps, cleft and knees. Liposomes are the best carrier for effective delivery of bioactives in the deep skin areas. In the present study, a comparative study of liposomes was carried out using thin film hydration and curvature tuned methods. Liposomes were prepared using cholesterol, soy lecithin and Span 80. The liposomes were evaluated for physical characterization, morphology, surface charge and release properties. Liposomes prepared by the thin film hydration method (formulation TACTL2) had better properties compared to liposomes prepared by the curvature tuned method (formulation TACCT2) in terms of entrapment efficiency (78.5±1.8% vs 53.4±5.6%), particle size (411.8 nm vs 630 nm), surface morphology(round and dispersed particles vs aggregates and lumps), and release profile (70.1% vs 32.87% in 12 h). Based on the results it is concluded that the thin film hydration method is better than a curvature tuned method for the preparation of liposomes. Keywords : Curvature tuned method; film hydration method; liposomes; particle size; psoriasis
Marmara University