Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2020 , Vol 24 , Issue 3
Compression force effect on characteristics of loratadine-succinic acid cocrystal prepared by slurry method
Dwi SETYAWAN1,Abhimata PARAMANANDANA1,V. Eres ERFADRIN1,Retno SARI1,Diajeng Putri PARAMITA2
1Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Mulyorejo 60115 Surabaya, Indonesia
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga, Mulyorejo 60115 Surabaya, Indonesia
DOI : 10.35333/jrp.2020.163 Loratadine belongs to second generation antihistamine (H1) drug and is known to form cocrystal with succinic acid in stoichiometry of 1:1 using slurry method. This study was conducted to further investigate cocrystal phase behavior upon compression. Sample of cocrystal phase was compressed with various compression forces into tablet form on 10 mm diameter punch. Then, the tablet was characterized for the mechanical properties and physical characterization was conducted using Differential Thermal Analysis (DTA), X-ray Powder Diffraction (XRPD), and Scanning Electron Microscope (SEM). According to tensile strength profile, cocrystal phase showed better mechanical property as it possessed higher tensile strength value compared to loratadine alone. DTA thermograms exhibited succinic acid characteristic peak alongside with endothermic peak of cocrystal phase which were compressed on higher force. It suggests that cocrystal undergoes partial dissociation to the starting components under compression. Powder diffractograms showed reduced intensity of tableted cocrystal compared to powder one for all compression force. SEM photomicrograph observed a loss of particle boundaries of cocrystal upon compression, as sintering phenomena occurred. It is predicted that compression force can influence physical characteristics of cocrystal of loratadine-succinic acid by driving dissociation and sintering phenomena. Keywords : Cocrystal; compression force; loratadine; physical characterization; succinic acid
Marmara University