Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2020 , Vol 24 , Issue 3
In vitro effects of methylsulphonylmethane in MCF7 cells
Işıl YILDIRIM1,Çağdaş AKTAN2
1Vocational High School, Pharmacy Services Program, Biochemistry Area, Beykent University, 34500, İstanbul, Turkey
2Department of Medical Biology, Faculty of Medicine, Beykent University 34500, İstanbul, Turkey
DOI : 10.35333/jrp.2020.154 Methylsulphonylmethane (MSM) is the best source of organic sulfur with the best bio-utilization in the body. MSM provides Sulphur support to fragile tissues such as hair. It provides elasticity to connective tissue. It is required for collagen production. Despite its many advantages, there are only few published papers about the anticancer research regard to MSM, no known studies on Bioinformatics Analysis and the possible mechanisms such an effect remain unknown. Therefore, we aimed to investigate the anticancer effects of MSM associated with a bioinformatics analysis on the breast cancer cell MCF7 and to give the information about possible molecular mechanisms. A cytotoxicity assay was performed using the MTT method. The cell migration analysis was performed using wound healing analysis. An apoptotic effect was performed by DNA fragmentation analysis. A Bioinformatics analysis was performed using a protein data bank. Study results indicated that this component exhibited an anti-proliferative effect as based on dosage increases and it showed apoptotic effects at high concentrations on MCF7 cells and results were supported by previous studies. Consequently, a detailed study of the molecular mechanisms of this matter would allow for the identification of possible new targets for breast cancer treatments. Keywords : Methylsulphonlymethane; apoptosis; cytotoxicity; cysteine; bioinformatics analysis
Marmara University