Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2020 , Vol 24 , Issue 2
Effects of vitamin C supplementation on the glycemic control and cardiovascular risk in Type II Diabetes Mellitus
Praveen DEVANANDAN1,Ranadheer Chowdary PUVVADA2,Vijey Aanandhi MUTHUKUMAR3
1Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, Tamilnadu, India
2Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, Tamilnadu, India
3Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, Tamil Nadu, India
DOI : 10.35333/jrp.2020.134 The oral hypoglycaemic agents as well as injectable insulin does not significantly alter the oxidative stress in the diabetes mellitus patients. Being an antioxidant Vitamin C (ascorbic acid) might help in tackling the adversities of reactive oxygen species. A randomized placebo controlled study was carried out with parallel assignment of both the test group and control group of patients. The intervention model included metformin 500mg twice daily and a placebo once daily for control group. Alternatively, Vitamin C chewable tablets were given for the other group along with metformin 500mg twice daily. Our study postulates that there is a significant reduction in the fasting blood glucose, glycosylated haemoglobin levels, troponin T levels and Framingham risk score in participants who received ascorbic acid supplementation along with regular metformin. The supplementation of Vitamin C along with Metformin was well tolerated and did not cause any serious adverse drug reactions. The cheaper cost adjuvant approach with Vitamin C may be beneficial in patients in reducing the cardiovascular risk as well as to maintain an appropriate glycaemic control Keywords : Diabetes Mellitus; ascorbic acid; glycemic control; cardiovascular risk
Marmara University