Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2020 , Vol 24 , Issue 1
5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents
Ahmet Serhat EKİNCİ1,Jan MONCOL2,Vagolu Siva KRISHNA3,Dharmarajan SRIRAM3,Keriman ÖZADALI-SARI1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turke
2Department of Inorganic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia
3Medicinal Chemistry & Antimycobacterial Research Laboratory, Pharmacy Group, Birla Institute of Technology & Science – Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad, Andhra Pradesh, India
DOI : 10.35333/jrp.2020.110 This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds (2a and 2c) were determined by the single-crystal X-ray diffraction study. Among the target compounds, 2-(4-ethoxyphenyl)-5-methyl-3-(phenylamino)thiazolidin-4-one (2g) was promising with a minimum inhibitory concentration of 12.5 μg/mL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity. Keywords : Antimycobacterial; tuberculosis; 4-thiazolidinone; single-crystal X-ray diffraction
Marmara University