¹Chitkara College of Pharmacy, Chitkara University, Punjab, India DOI : 10.35333/jrp.2019.32 In the present study, microwave assisted synthesis of starch and glycine (1:1, 1:3, 1:5) conjugates was performed for its application as tablet superdisintegrant. Chemical interactions between starch and glycine were studied by FTIR analysis. Scanning electron microscopy (SEM) was performed to study the surface morphology of conjugates. An innovative tool, SeDeM expert system, was employed to provide index for good compressibility (IGCD) and dispersibility (IGD) against the parameters for the powder under study. IGCD mainly comprises of six main factors (derived from 15 practical pharmaceutical range factors) they initially indicate whether powder has the ability to undergo the process direct compression. IGD (derived from 3 factors) indicates whether the tablets formulated using the given powders are suitable to be used fast disintegrating tablet formulations. SeDeM expert system is an innovative tool for assessing direct compression suitability materials and disintegration potential of the tablets. Optimum ratio of starch and glycine was found to be 1:5 with the IGCD score of 6.4 which was comparatively much better than the other selected ratio’s. Keywords : Starch glycine conjugate; superdisintegrant; fast disintegrating tablets; SeDeM expert system