Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2018 , Vol 22 , Issue 2
Development and optimization of venlafaxine hydrochloride floating microspheres using response surface plots
Sachin Kumar1,Rupa Mazumder3
1NKBR College of Pharmacy & Research Centre, Meerut Hapur Road, Meerut, India
2Dr. A.P.J. Abdul Kalam Technical University, Sector 11, Jankipuram, Lucknow, India
3Pharmacy Institute, Noida Institute of Engineering and Technology, 19, Knowledge Park-II, Institutional Area, Greater Noida, Uttar Pradesh 201306, India
DOI : 10.12991/mpj.2018.65 The current study deals with the development of floating microspheres of venlafaxine hydrochloride. This drug is known as a serotonin-norepinephrine reuptake inhibitor and used to treat depression. Due to the short elimination half life of 4-5 h, the drug has to be administred 2-3 times in a day to maintain the plasma concentration. Thus an attempt was made to decrease the dosing frequency. The microspheres were prepared by non-aqueous solvent evaporation method. The microspheres were evaluated for particle size and morphology using a photomicroscope and scanning electron microscopy, respectively. The incorporation efficiency of microspheres of batch F2 and F6 showed entrapment of 60.6% and 57.2%, respectively. The mean diameters of particles for all batches were found in the range of 226.15 ± 24.37 to 283.37 ± 21.56 μm. The Fourier transform infrared spectroscopy revealed absence of any drug - polymer interactions. The microsphers remained buoyant for more than 12 h. The drug release from developed microspheres followed Fickian diffusion with swelling. The results suggested that the developed floating microspheres containing venlafaxine hydrochloride could enhance drug entrapment efficiency, reduce the initial burst release and modulate the drug release. Keywords : Floating microspheres; gastroretentive floating system; response surface plots; venlafaxine hydrochloride
Marmara University