Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2016 , Vol 20 , Issue 3
Chemical Constituents and Bioactivities From the Leaves of Beilschmiedia Glabra Kosterm (Lauraceae)
Wan Mohd Nuzul Hakimi Wan Salleh1, Farediah Ahmad1, Khong Heng Yen2, Razauden Mohamed Zulkifli3
1Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia
2School of Chemistry and Environment Studies, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM) Sarawak, Jalan Meranek, 94300 Kota Samarahan, Sarawak, Malaysia
3Department of Bioscience and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia
DOI : 10.12991/mpj.20162079371 Two butanolides, subamolide D (1) and subamolide E (2), along with β-sitosterol (3), β-sitostenone (4), lupeol (5), taraxerol (6), and 24-methylenelanosta-7,9(11)-diene-3β,15α- diol (7) were isolated from the leaves of Beilschmiedia glabra. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH• radical scavenging, antimicrobial, acetylcholinesterase and lipoxygenase inhibitory activities. Compounds 1 and 2 displayed the strongest lipoxygenase assay with an IC50 value of 5.1 and 5.5 μM, respectively. All compounds showed weak activity on DPPH• radical-scavenging, antimicrobial, and acetylcholinesterase inhibition assays. Keywords : Lauraceae, Beilschmiedia, DPPH•, antimicrobial, acetylcholinesterase, lipoxygenase
Marmara University