Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2016 , Vol 20 , Issue 3
The Importance of Irp as Regulators of Iron Metabolism in β Thalassemia Patients
Yasemin KARTAL2, Dilek KAYA-AKYÜZLÜ1, Zeliha Kayaaltı1
1Ankara University, Institute of Forensic Sciences, Ankara, TURKEY
2Hacettepe University, Faculty of Medicine, Department of Physiology, Ankara, TURKEY
DOI : 10.12991/mpj.20162098496 Thalassemia is a hereditary blood disease. Beta (ß)-thalassemia which caused by a point mutation on ß-globin gene localized on short arm of chromosome 11 as a cluster, is an autosomal recessive and also one of the most common genetic diseases in worldwide. In other words, this disease is characterized by malfunctions during the globin chain synthesis of hemoglobin synthesis process. Unbalanced globin chain synthesis is the major cause of low level hemoglobin production leading to anemia. Current therapy for this disease includes regular blood transfusions and iron chelation. Excessive hemolysis, increased intestinal iron absorption as well as frequent blood transfusions during therapy results in chronically increased iron load and consequently oxidative stress. Iron homeostasis is provided by iron regulatory proteins (IRPs) in body. Therefore, variants of these proteins lead to differences in iron uptake and the storage. In this review, the role of IRP-1 and IRP-2 in iron uptake and the effect of oxidative stress consequent upon the iron toxicity in thalassemia individuals will be examined in detail. Keywords : IRP-1, IRP-2, gene polymorphism, oxidative stress and thalassemia
Marmara University