Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2011 , Vol 15 , Issue 1
Synthesis and characterization of triazenes derived from sulfonamides
Seda Ünsalan1, Pelin Çıkla1, Ş. Güniz Küçükgüzel1, Sevim Rollas1, Fikrettin Şahin2, Ömer Faruk Bayrak2
1MÜ. Eczacılık Fakültesi, Farmasötik Kimya AD., İstanbul, Türkiye
2Yeditepe Üniversitesi, Mühendislik ve Mimarlık Fakiltesi, Genetik ve Biyomühendislik Bölümü, İstanbul, Türkiye
DOI : 10.12991/201115439 A series of novel triazene derivatives 1-3, 1a-3a were synthesized by the coupling of diazonium salts of amines (sulfaguanidine, sulfapyridine, sulfamethoxazole) with N-methylaniline / p-nitroaniline in acidic media. The structures of the synthesized compounds were confirmed by the spectral data (UV, IR, 1H-NMR, APCI-MS) and elemental analysis. The effects of all the compounds on A 549 and L 929 cell lines growth were investigated. The cytotoxic and antitumor activities of these compounds have not been in vitro aganist A 549 and L 929 cell lines. Keywords : Triazene, sulfonamide, prontosil, azo reduction
Marmara University