Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1989 , Vol 5 , Issue 2
Spectrophotometric determination of maprotiline hydrochloride with 7,7,8,8-tetracyanoquinodimethan
Aysel Öztunç
A simple and very sensitive spectrophotometric method was developed for determination of maprotiline hydrochloride. The method was based on the reaction of maprotiline base with π-acceptor 7,7,8,8-tetracyanquinodimethan in acetonitrile at 80oC for 20 min. to yield an intensely coloured purple product. Absorbances were measured at 567 nm. A linear relationship existed between absorbance and concentration of maprotiline hydrochloride over 2*12 μg ml-1 concentration range. The proposed method was applied for determination of the drug in tablets and the results were compared with those obtained by the official NF XVI method throught t- and F- tests. Keywords :
Marmara University