Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2020 , Vol 24 , Issue 4
Formulation and optimization of gellan gum-poloxamer based dexamethasone mucoadhesive in situ gel
Seda RENÇBER1,Sinem Yaprak KARAVANA2
1Department of Pharmaceutical Technology, Faculty of Pharmacy, İzmir Katip Celebi University, İIzmir, Turkey
2Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, İzmir, Turkey
DOI : 10.35333/jrp.2020.201 The main objective of the present study was to formulate and evaluate mucoadhesive in situ buccal gels of dexamethasone based on gellan gum-poloxamer 407. Formulations were characterized for gelling capacity, drug content, pH, viscosity, rheological studies, mechanical studies and in vitro drug release. The drug content, clarity and pH of the formulations were found to be satisfactory. Mucoadhesive in situ gels showed thermoresponsive behavior, existing as a liquid at room temperature and gel at 30–37ºC. Formulations exhibited pseudoplastic flow and typical gel-type mechanical spectra (G′ > G″) at different frequecy values and 37ºC. Prepared gels resulted in preparations with desirable rheological features as well as texture (appropriate hardness, compressibility, adhesiveness, cohesiveness and elasticity) properties, which could benefit the therapeutic efficacy, by increasing the residence time and easiness for local application on the buccal mucosa. Additionally, the developed preparations exhibited sustained drug release up to 72 h as intended for these systems. Optimized formulation containing 14% w/v poloxamer 407 and 0.4% w/v gellan gum exhibited desired characteristics (mechanical and rheological properties) for developing buccal drug delivery systems. Thus, buccal dexamethasone loaded mucoadhesive in situ gel was found to be a promising formulation. Keywords : Dexamethasone; gellan gum; poloxamer; in situ gel; buccal drug delivery
Marmara University