Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2019 , Vol 23 , Issue 5
Application of SeDeM expert system in formulation and development of fast disintegrating tablets using starch-glycine conjugates as superdisintegrant
Inderbir SINGH1,Bhawna SHARMA1,Govind ARORA1
1Chitkara College of Pharmacy, Chitkara University, Punjab, India DOI : 10.35333/jrp.2019.32 In the present study, microwave assisted synthesis of starch and glycine (1:1, 1:3, 1:5) conjugates was performed for its application as tablet superdisintegrant. Chemical interactions between starch and glycine were studied by FTIR analysis. Scanning electron microscopy (SEM) was performed to study the surface morphology of conjugates. An innovative tool, SeDeM expert system, was employed to provide index for good compressibility (IGCD) and dispersibility (IGD) against the parameters for the powder under study. IGCD mainly comprises of six main factors (derived from 15 practical pharmaceutical range factors) they initially indicate whether powder has the ability to undergo the process direct compression. IGD (derived from 3 factors) indicates whether the tablets formulated using the given powders are suitable to be used fast disintegrating tablet formulations. SeDeM expert system is an innovative tool for assessing direct compression suitability materials and disintegration potential of the tablets. Optimum ratio of starch and glycine was found to be 1:5 with the IGCD score of 6.4 which was comparatively much better than the other selected ratio’s. Keywords : Starch glycine conjugate; superdisintegrant; fast disintegrating tablets; SeDeM expert system
Marmara University