Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2019 , Vol 23 , Issue 2
Effect of aerial part and root extracts from Ferulago mughlae Peșmen and Ferulago sandrasica Peșmen & Quézel growing in Turkey on erectile dysfunction in streptozotocin-induced diabetic rats
1Department of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
2Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Ankara, Turkey
3Department of Pharmacology, Faculty of Pharmacy, Çukurova University, Adana, Turkey
4Department of Pharmacology, Faculty of Pharmacy, Ankara University, Ankara, Turkey
DOI : 10.12991/jrp.2019.129 Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors. In Turkish traditional medicine, the roots from some members of this genus are utilized as aphrodisiac, so we determined to show in vitro relaxant effect of F. mughlae Peșmen and F. sandrasica Peșmen & Quézel species extracts on corpus cavernosum (CC). A totality of 20 adult male Sprague-Dawley rats (diabetic and control groups) were induced by single intraperitoneal injection of 40 mg/kg of Streptozotocin. In vitro organ bath tests were carried out on rats to evaluate isometric pressure. Tissues were stretched with phenylephrine (Phe), and relaxation responses relevant to acetylcholine (ACh, 1 mM ), sodium nitroprusside (SNP 0.1 μM ) and electrical field stimulation (EFS, frequency 20 Hz) were gained. Whole these concentration-response curves were replicated with aqueous extracts obtained from the aerial parts and roots. The extracts were active in both groups. It was found that root extracts of F. mughlae and F. sandrasica yielded 97.80% and 97.55% relaxation. Among the extracts of roots (especially roots of F. mughlae) showed the best activity. On the other hand, lyophilized aqueous extracts of aerial part (especially F. sandrasica) showed the worst activity. Based on this findings, the roots of this species deserve further in vivo assessments for their aphrodisiac potential. Keywords : Aphrodisiacs; Apiaceae; Ferulago; erectile function
Marmara University