ACTA Pharmaceutica Sciencia 2016 , Vol 54 , Num 1
Hepatoprotective Effects of Coriandrum Sativum Essential Oil Against Acute Hepatotoxicity Induced by Carbon Tetrachloride on Rats
Hanefi Özbek 1 Neriman İpek Kırmızı 2 Nureddin Cengiz 3 Ender Erdoğan 4
1 Istanbul Medipol University, School of Medicine, Department of Pharmacology, Istanbul
2 Istanbul Medipol University, Vocational School of Health Services, Istanbul
3 Sakarya University, Faculty of Medicine, Department of Histology-Embriology, Sakarya
4 Selçuk University, Faculty of Medicine, Department of Histology-Embriology, Konya
DOI : 10.23893/1307-2080.APS.0543 The aim of this study was to evaluate effect of Coriandrum sativum (CS) essential oil in rat model of carbon tetrachloride (CCl4) induced liver toxicity. Experimental groups were formed as follows: isotonic saline solution (ISS), silibinin, CS-1 (0,3ml/ kg), CS-2 (0,6 ml/kg). Agents were administered intraperitoneally. Blood and liver tissues were collected at the end of the study ended. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured. Liver tissues were evaluated histopathologically. One-way analysis of variance (ANOVA) was used for statistical analyses.As a result silibinin and CS-2 decreased blood AST and ALT levels of their groups and these biochemical results were supported by histopathological results. In conclusion this study has provided evidence that Coriandrum sativum essential oil has significant hepatoprotective effect on carbon tetrachloride induced liver toxicity in rats. Keywords : Coriandrum sativum, hepatoprotective activity, carbon tetrachloride, rats, essential oil

Istanbul Medipol University