Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2016 , Vol 20 , Issue 3
Investigation on Binding Properties of Grewia Asiatica Mucilage in Tablet Formulations
Archana Chaudhary1, Giriraj T Kulkarni2, Rajendra Awasthi1, Pravin Kumar1
1Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Kangra, Himachal Pradesh, India 176031
2Amity Institute of Pharmacy, Amity University, Sector 125, Noida 201303, Uttar Pradesh, India
DOI : 10.12991/mpj.20162032588 The binding property of Grewia asiatica mucilage was evaluated at 0.25-0.1% concentrations. The mucilage was extracted by cold maceration method and characterized for its swelling index, moisture absorption capacity, solubility, organoleptic characters and purity. The mucilage was also investigated for its toxicity, microbial growth and texture. Tablets were prepared by a wet granulation using paracetamol as a model drug. The granules were evaluated for micromeritics properties, percentage of fines and moisture content. The tablets were evaluated for appearance, weight variation, friability, thickness, hardness, disintegration time, drug content and in vitro drug release. It was observed that the friability percentage was decreased with an increase in mucilage concentration. Hardness of the tablet was increased with an increase in mucilage concentration and was found to be in the acceptable range. Disintegration time was found to be less than 15 min for all the four batches. Drug content was found to be in the range of 93.0- 98.08% for all the formulations. More than 80% of the drug was released within 30 min during the in vitro dissolution study. Keywords : Grewia asiatica, excipients, mucilage, binder, Kitazawa.
Marmara University