Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2015 , Vol 19 , Issue 1
Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril
Oya KERIMOGLU1, Sevinc SAHBAZ1, Ahmet Ozer SEHIRLI2, Betul DORTUNC1, Goksel SENER2
1Faculty of Pharmacy, Department of Pharmaceutical Technology Marmara University, 34668 Haydarpaşa, Istanbul, Turkey
2Faculty of Pharmacy, Department of Pharmacology Marmara University, 34668 Haydarpaşa, Istanbul, Turkey
DOI : 10.12991/mpj.2015198612 The objective of this study was to evaluate the mechanical properties of transdermal therapeutic systems (TTS) containing captopril together with synthetic and pH independent polymers, Eudragit RL 100 and RS 100. The formulations were characterized in terms of their adhesiveness and bioadhesiveness by using texture analyser. These optimum formulations were chosen according to the results of our previous study regarding in vitro dissolution and ex vivo diffusion rate studies through excised human skin by using Franz Diffusion Cell. Results indicated that the mechanical properties of the formulations were suitable to be used as a transdermal patch. Keywords : captopril, transdermal therapeutic system, patch adhesiveness, patch bioadhesiveness, texture analyser
Marmara University