Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1997 , Vol 13 , Issue 1
Synthesis ans antimicrobial screening of 2,3-benzo[“]oxazepine analogs
P. Öziç,H.S. Güneş,M. Çizmecioğlu,V. Pabuçcuoğlu,B. Gözler,B. Özçelik,U.Abbasoğlu
N-oxidation and subsequent ring enlargement through the Meisenheimer Rearrangement of the properly substituted tetrahydroisoquinolines yielded nine novel 7.8- dimethoxy-3-methyl-1- (substitutedphenyl)-1,3,4,5- tetrahydro-2,3-benzo[e]oxazepine derivatives. Characterization of the final products have been done by UV, EIMS. 1H and 13C NMR spectroscopy. These compounds, together with seven more analogs which have been screened for their antimicrobial activity, using the microdilution technique. The results indicate that none of the compounds possesses any significant antibacterial or antifungal activity against the microorganisms tested in this study. Keywords : 2.3 - benzo[e] oxazepines. 1,2,3,4,- tetrahydroisoquinoline N-oxides, Meisenheimer Rearrangement, ring enlargement, antimicrobial activity
Marmara University