Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1995 , Vol 11 , Issue 1 - 2
Effects of opipramol on hepatic glutathione levls in rats
Ö. Ersoy,E. Acar Oray
It was investigated if, opipramol (OPI), a tricyclic antidepressant, which has a corresponding double bond for epoxidation, causes any decrease in hepatic glutathione (GSH) level. This was done by administering rats with OPI and then determining their hepatic GSH levels by means of a spectrophotometric method. Both repeated and single low dose (4 mg/kg), and high dose (50 mg/kg) OPI administration produced statistically significant decreases in hepatic GSH level in rats. Keywords : Opipramol, glutathione, liver
Marmara University