Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2024 , Vol 28 , Issue 3
Improved flowability, mechanical and dissolution properties of metronidazole obtained from crystallo coagglomeration technique for direct tableting
Abba Khalid ABDULLAHI1,Adeniji Kehinde OLOWOSULU1,Teryila Suzanne ALLAGH1
1Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University Zaria, Nigeria DOI : 10.29228/jrp.744 There has recently been growing interest in exploring the potential of direct compression (DC) method of tableting as an alternative to the conventional granulation technique. This approach involves straightforward powder mixing and compression, resulting in time and cost savings, and has successfully been applied to various drugs. However, drugs require good micromeritic qualities, such as flowability, good reproducible compression behaviour to be directly compressed because it affects its in-vitro and in-vivo performance. Since many active pharmaceutical ingredients lack these qualities, the crystallo co-agglomeration technique hasemergedas a potential area of research for particle design,utilised in the development of active ingredients best suited for direct compression of tablet dosage forms. Pure metronidazole exhibited significantly higher Carr’s index, Hausner’s ratio, and angle of repose of 41.93°±1.05, indicating cohesiveness and irregular shape of the crystals.Whereas the crystallo-co-agglomerates were found to have an angle of repose of 29.33°±0.96, denoting an improvement in the flowability of the agglomerated crystals. Improvements in mechanical handling parameters was revealed in metronidazole co-agglomerate tablets produced with DC excipients (F1, F2). These tablets were found to be more robust and of higher quality compared to those formulated using pure metronidazole (F4, F5, F6), which were of no significant difference with metronidazole formulated via wet granulation method (F7, F8, F10, F11).In-vitro dissolution studies of metronidazole co-agglomerates tablets showed no significant difference in the percentage drug release profilebetween tablets produced via direct compression and wet granulation method. Thus, the crystallo co-agglomeration technique can be effectively used in the formulation of metronidazole tablets by direct compression using Avicel® and Prosolv®, presenting an efficient and streamlined approach to tablet manufacturing. Keywords : Crystallo co-agglomeration; Metronidazole co-agglomerates; Direct compression; Wet granulation; Pure metronidazole
Marmara University