Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1994 , Vol 10 , Issue 1
Synthesis and characterization of some thiourea derivatives from 1,2,4-triazoline-3-thiones
İlkay Küçükgüzel,Sevim Rollas,Mert Ülgen
A number of N - substituted -N’-[4-(-methyl/phenyl- 2,4- dihydro - 3H - 1,2,4- triazole - 3- thione -5- yl) phenyl] thiourea derivatives were obtained by the reactions of 5- (4- aminophenyl)-4- methyl- 2,4 - dihydro- 3H-1,2,4- triazole -3- thione with methyl,allyl, phenyl and p- bromophenyl isothiocyanates; and also by the reactions of 5- (4- aminophenyl) -4- phenyl - 2,4 - dihydro-3H-1,2,4 - triazole - 3 - thione w,th methyl, ethyl, allyl, cyclohegzyl, phenyl and p - chlorophenylisothiocyanates. The structures and purity of synthesised compounds were confirmed using UV, IR and MASS spectroscopic techniques. Compounds (V c,d, i, j) exhibited no molecular ion peaks in the mass spectra were also confirmed with elemental analysis. Keywords :
Marmara University