¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, İstanbul University, Beyazıt, İstanbul 34116, Turkey
²Department of Biochemistry, Faculty of Pharmacy, İstanbul University, Beyazıt, İstanbul 34116, Turkey DOI : 10.29228/jrp.684 Herein, we report the in vitro Acetylcholinesterase (AChE) inhibitory activities of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. The compounds were characterized by diverse spectral methods and reported by our research team previously. As a novelty we conducted in vitro AChE inhibitory activities of the title compounds and performed in silico studies to provide insight related to activity mechanism of the compounds. Compound 4f displayed the best biological activity within our compounds with 69.92% enzyme inhibition value (at a final concentration of 0.08 mg/mL) and 0.0245 mg/mL IC₅₀ value. Keywords : Synthesis; acetylcholinesterase; biological evaluation; molecular modeling