Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1993 , Vol 9 , Issue 2
Investigation of the effect of defibrotide on plasma proteins of atheroschlerotic subjects by isocratic HPLC
Ersin Bayrakdar,Ertuğrul Yurtsever,Turay Yardımcı
In this work 10 mg/ kg defibrotide was injected (i.v.) to 8 cases with atherosclerosis. Blood samples were taken before and 2 hours after defibrotide administrations. The total protein concentrations in plasma were determined by Lowry method. The protein concentrations were 90.16 ± 9.60 mg/ ml and 96.40± 7.40 mg / ml before and after defibrotide applications respectively. This increase was insignificant. The plasma proteins were also separeted according to their molecular weights by isocratic HPLC. Although some increases on the protein content of all the fractions two hours after a single administration of defibrotide were observed, these increases were statistically insignificant. Keywords :
Marmara University