Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 6
The production of curcumin-loaded PLGA/PEG nanoparticle for the treatment of Alzheimer’s disease
Ece GULER1,Muhammet Emin CAM1
1Department of Pharmacology, Faculty of Pharmacy, Marmara University, Basıbuyuk 34854 Istanbul, Türkiye
2Department of Pharmacology, Faculty of Pharmacy, Istanbul Kent University, Kagıthane 34406 Istanbul, Türkiye
DOI : 10.29228/jrp.527 Alzheimer's disease (AD) is the most common type of dementia in the world. This neurodegenerative disease affects 6.5 million people's lives by leading to functional impairments such as memory loss and cognitive regression. In the treatment of AD, there is no drug for radical treatment in the worldwide. Current treatment strategies provide relief to the symptoms. Therefore, curcumin (CUR) was preferred as a promising alternative therapeutic approach in this study. By using the double emulsion solvent evaporation technique, PLGA/PEG nanoparticles were produced and CUR was loaded to these nanoparticles (CNP). After that, the chemical structures and morphologies of CNP and PNP were analyzed by using FTIR and SEM. As a result, it was proven that these nanoparticles were produced by using PLGA and PEG polymers and CUR was loaded to these nanoparticles successfully. Keywords : Alzheimer’s disease; curcumin; nanoparticle; PLGA; PEG
Marmara University