Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 2
Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation
Faika BAŞOĞLU-ÜNAL1,Selin CİMOK1,Efe Doğukan DİNCEL1,Lieve NAESENS4,Nuray ULUSOY-GÜZELDEMİRCİ1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt 34116 İstanbul, Turkiye
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, European University of Lefke, Lefke, Northern Cyprus, TR-10 Mersin, Turkiye
3Graduate School of Health Sciences, Istanbul University, Fatih, 34126 Istanbul, Turkiye
4Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium
DOI : 10.29228/jrp.372 This paper aimed to synthesize novel compounds carrying imidazo[2,1-b]thiazole nucleus, characterize them with various spectroscopic methods, moreover evaluate their antiviral activity. All novel derivatives were evaluated for their antiviral activity against Coxsackie B4 virus, Respiratory syncytial virus, Influenza A/H1N1 virus, Influenza A/H3N2, and Influenza B virus. Some of the compounds, particularly the derivatives carrying 4- methylphenyl and 4-bromophenyl moiety, exhibited higher and comparable activities against both Coxsackie B4 and Respiratory syncytial viruses, moreover the compounds with N-propyl and N-butyl at thiazolidinone ring showed high antiviral activities against Influenza Influenza A/H3N2 viruses. Consequently, the results obtained from in vitro assay data shed light on improving novel antiviral. Keywords : Imidazo[2,1-b]thiazole; 4-thiazolidinone; antiviral activity; coxscakie b4 virus, influenza
Marmara University