Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 2
O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies
Abdullah Levent ALPARSLAN1,Ercument KARASULU2,Gulbeyaz Yildiz TÜRKYILMAZ3,Dogan UVEY4
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Istinye University, Istanbul, Turkey
2Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Izmir, Turkey
3Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Izmir, Turkey
4Department of History of Pharmacy and Ethics, Faculty of Pharmacy, Istinye University, Istanbul, Turkey
DOI : 10.29228/jrp.367 Microemulsions are ideal carriers for poorly soluble substances. They increase the absorption of drugs with low bioavailability. Methotrexate (MTX), which is used internally in cancer and psoriasis and has many side effects and it is less soluble in water and its passage through the skin is problematic due to its high molecular weight. An O/W microemulsion formulation containing MTX has been developed in order to reduce the side effects of the drug, not to have a first pass effect on the liver, to increase its bioavailability in topical use and to provide ease of use to patients. The releasing profiles of the gel formulation, prepared by reducing the fluidity of these formulations by polymers, were investigated through the nylon membrane. Mostly W/O microemulsion systems are available due to design of preparations but in this study O/W microemulsions and gel forms containing MTX were designed for topical use. Innovation side of trials will inspire in vivo studies and clinical studies that may cause less harm to patients dermatologically and provide optimal effect. Keywords : Microemulsion; O/W; hydrogel; metotrexate; franzcell; topical, release
Marmara University