Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 2
Strategic application of a mixed polymeric micellar solid dispersion system to domperidone for improved biopharmaceutical characteristics
Shimul HALDER1,M. A. K. AZAD2,Md. Shamiul ISLAM3,Istiak HOSSEN2,Madhabi Lata SHUMA4,Eva Rahman KABIR2
1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
2Department of Pharmacy, BRAC University, Mohakhali, Dhaka-1212, Bangladesh
3Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
4Department of Pharmacy, Stamford University Bangladesh, Siddeswari, Dhaka-1217, Bangladesh
DOI : 10.29228/jrp.366 The main objective of this work was to improve the biopharmaceutical properties of Domperidone (DMP)- loaded mixed polymeric micellar solid dispersion (MMSD). The apparent solubility of DMP in polymer solutions was used to choose suitable amphiphilic polymers for the preparation of an MMSD system. Different ratios of Soluplus® and Kolliphor® P188 (ranging 0–80 %w/w) have been used to prepare the MMSD-DMP by solvent evaporation method and physicochemically characterized. Among the tested different ratios of Soluplus® and Kolliphor® P188, the optimal ratio of polymers was selected based on the solubility and surface properties. The solubility of optimized MMSD-DMP in water was found more than 17 times higher compared to that of the crystalline DMP. The crystallinity evaluations of the optimized formulation revealed amorphization of DMP, resulting in enhanced solubility. The drug release pattern did not change significantly between formulations of MMSD-DMP produced by rotary vacuum drying and freeze drying. From these findings, MMSD approach might be a promising dosage option for DMP, offering enhanced biopharmaceutical behaviors leading to improved oral absorption. Keywords : Domperidone; mixed polymeric micellar solid dispersion; Soluplus®; Kolliphor® P188; solubility, dissolution
Marmara University