¹Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria
²Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria
³Department of Pharmaceutical and Medical Chemistry, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria
⁴Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Federal University Oye Ekiti, Nigeria
⁵Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Gombe State University, Gombe, Nigeria DOI : 10.29228/jrp.182 Ibuprofen is an important and commonly used nonsteroidal anti-inflammatory medication (NSAID). Its medicinal potentials are however severely hindered due to its poor water solubility and low oral absorption. A self-nano emulsifying drug delivery system (SNEDDS) is a lipid formulation that takes advantage of the solubilizing capacity of a mixture of oil, surfactant, and cosurfactant to improve intestinal permeability. The aim of this study is to develop SNEDDS of ibuprofen employing both labrafac CC and a natural lipophile (N-L) (vegetable oil) from pressed sesame seeds to improve the anti-inflammatory activity of ibuprofen. The formulation was stable against phase separation and drug precipitation, exhibited rapid emulsification within 5 s to yield an emulsion with a mean droplet size of 27.23 nm and showed a significant (p = 0.000) increase in anti-inflammatory properties compare to the aqueous suspension of the standard drug and each treatment agent across the test period. Overall, SNEDDS of ibuprofen with desirable physicochemical properties and improved anti-inflammatory activities were successfully developed using an un-refined lipophile obtained from pressed sesame seed. Keywords : Self-emulsification; nano; bioavailability; ibuprofen; anti-inflammatory