ACTA Pharmaceutica Sciencia 2004 , Vol 46 , Num 1
PREPARATION AND CHARACTERIZATION OF POLYETHYLENE OXIDE HYDROGELS WITH CYTISINE
M DİMİTROV, D DOTCHEVA, N LAMBOV
Department Pharmaceutical Technology, Faculty of Pharmacy, Medical University, Dumav Str., Sofia, Bulgaria This paper presents a study of the possibilities for preparation of hydrogel systems via UV initiated crosslinking of Polyoxyethylene oxide (Polyox). Cytisine was included as a model drug in the matrix. The investigations carried out in vitro have shown that the crosslinking of Polyox results in hydrogels, that swell within 120 - 180 min and the loaded drug in them is with a retarded release, The Cytisine concentration in the matrix and the degree of crosslinking turned out to be the major factors determining the release rate. Keywords : HYDROGELS, UV-IRRADIATION, POLYETHYLENE OXIDE, CYTISINE

Istanbul Medipol University