Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Journal of Research in Pharmacy
1986 , Vol 2 , Issue 1
Spectrophotometric determination of dapsone in tablets with 1,2-naphthoquinone-4sulphonic acid sodium salt
A spectrophotometric method for the assay of dapsone based on the chromophore formation after reaction with 1,2-naphthoquinone-4sulphonic acid sodium salt was developed. The reaction proceeded quantitatively at pH 2 and 60oC within 30 minutes when the molar ratio of reagent to dapsone was 10. After completion of the reaction, formed derivative (dapsone- NQ) was extracted from the aqueous solution with chloroform/ n-butanol (3:1). Dapsone- NQ shows maximum absorbance at 440 nm. The absorbance is linear (r=0.9999) over 2-30 µg.ml-1 concentration range. The proposed method has been successfully applied to the determination of dapsone in tablets and the results were compared with those obtained by the USP XX method using t- and F- tests.
Keywords :