¹Department of Pharmacognosy, Pharmacology and Botany, Faculty of Pharmacy, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine
²Department of Clinical Pharmacy, Pharmacotherapy, Pharmacognosy and Pharmaceutical Chemistry, Faculty of Post-graduate Education, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine
³Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine
⁴Department of Organic and Bioorganic Chemistry, Faculty of Post-graduate Education, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine DOI : 10.29228/jrp.100 Present manuscript describes the design, synthesis and antimicrobial activity of novel [1,2,4]triazіno[2,3-c]quinazoline – pyrazoline hybrids. The combination of pyrazoline cycle with [1,2,4]triazіno[2,3-c]quinazoline heterocyclic fragment was substantiated as promising approach for development of novel antibacterial and antifungal agents. The simple and effective synthetic procedure for target heterocyclic hybrids was proposed. The structures of obtained compounds were verified by appropriate physicochemical methods, the features of 1H NMR-spectral characteristics were described as well. It was shown that synthesized compounds reveal significant growth inhibitory activity against Candida albicans strain. Keywords : quinazoline; pyrazoline; heterocyclic hybrids; antimicrobial activity; Candida albicans