Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 5
In silico investigation of wound healing potential of some compounds in tubers of Asphodelus species with GSK3-β protein
Halil AKSOY1,Turgut ŞEKERLER1,Naz Mina MERT2
1Department of Biochemistry, Faculty of Pharmacy, Marmara University, Maltepe, 34854 İstanbul, Turkey
2Computational Biology and Bioinformatics, Kadir Has University, Fatih, 34083 İstanbul, Turkey
DOI : 10.29228/jrp.65 Wound healing is a process that involves biochemical processes such as inflammation and cell proliferation and is controlled by many proteins. It is known that one of the most effective factors in this process is the inhibition of GSK3-β protein. In current study, in silico wound healing activity of the some compounds found in the tubers of Asphodelus species used as a wound healing in traditional medicine were investigated. For this purpose, the interactions between the compounds and GSK3-β protein were studied in silico. As a result of the study, it has been determined that and stigmasterol, β-sitosterol and emodin molecules are effective. Keywords : Asphodelus species; β-sitosterol; emodin; GSK3-β protein; stigmasterol; wound healing activity
Marmara University