¹Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali- 3814, Bangladesh
²Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh DOI : 10.29228/jrp.55 The role of elemental zinc has been documented for different types of disorder. The present study's objective was to evaluate zinc supplements (zinc sulphate heptahydrate) effect on neurological behavior in mice models. The study was conducted on mice for 28 days. Effect on neurological behaviors was assessed by conducting various behavioral tests, including Elevated plus maze (EPM) test, Hole-board test, Hole cross test, and Open field test. After the experimental period, the zinc supplement group spent less time in the open arm (p<0.05), indicating an anxiety state. This result was supported by a reduced level of head dipping activity (p<0.05) in the elevated plus maze test. Again, the mice in the supplemented group showed an increased number of movements between the holes (p<0.05) in the hole-board test followed by the reduced number of squares crossed (p<0.05) in the open field test compared to the control group. These findings support the notion of anxiety state, lack of neophilia or decreased locomotion activity, or less sedation. Based on the present study's findings, it can be concluded that all the behavioral tests indicate that regular treatment with zinc may show an impaired effect on the brain leading to mood and behavioral disorders by interfering with the zinc regulations homeostasis. So, zinc mineral should be supplemented to users only having specific zinc-deficit disease conditions. Keywords : Zinc; central nervous system (CNS); locomotion; neophilia; anxiety