¹Department of Pharmaceutical Technology, Faculty of Pharmacy, Atatürk University, 25240, Erzurum, Turkey DOI : 10.29228/jrp.57 Today, treating diseases requires increasing the patient's living standard rather than just applying a classical treatment protocol. In this study, it was aimed at facilitating drug intake, reduce the dose of the active substance, reduce the number of daily doses to be taken, reduce or eliminate possible side and/or toxic effects, transport the active substance to the target area and make as much bioavailability from the active substance as possible too. For this purpose, in our study, hydrogel bead formulations with ionotropic gelation technique were developed using ampicillin sodium as a model drug and sodium alginate and HPMC K100 as polymer. CaCl2 was used as a crosslinking agent. While developing a new drug delivery system formulation, size, morphology with SEM, in vitro release profiles, release kinetics, encapsulation efficiencies, drug loading capacities, yields, and swelling capacities, FT-IR and XRD analysis were evaluated in the hydrogel beads depending on the amount of the polymer and crosslinking agent. It has been made possible to extend the duration of drug action by changing the amount of polymer and crosslinker ratios in oral drug delivery of ampicillin sodium with alginate beads. Thus, it is likely to increase patient compliance as well as to reduce drug-related side and/or toxic effects with less dosing. Keywords : Ampicillin sodium; beads; drug delivery system; HPMC; sodium alginate